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Hormone secretion from pituitary tumors, although excessive and associated with unique phenotypic features, often retains intact trophic control. For example, dopaminergic agents appropriately suppress PRL secretion by prolactinomas, and dexamethasone may suppress ACTH secretion in patients with pituitary Cushing disease.
From Melmed S 2003 Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest 112:1603-1618, with permission.
