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. 2015 Mar 5;6:4. doi: 10.1186/s13100-015-0035-7

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© Schmitt et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Schematic of HERV-K(HML-2) provirus and splicing of rec and np9 mRNAs. Irrelevant proviral regions are omitted. rec mRNA is generated by a second splicing event of env mRNA removing most of the env gene region. Both rec and np9 mRNA utilize the same splice acceptor site just upstream of the 3′LTR. Because SD2 for rec mRNA is located within the 292-bp sequence missing in HML-2 type 1 proviruses, an alternative np9-specific SD2 is used instead also resulting in a translation frameshift when spliced to exon 3. Location of PCR primers used for amplification of rec and np9 mRNA/cDNA is indicated. Note that the lower provirus map is not drawn to scale. LTR, long terminal repeat.