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. 2015 Mar 5;6:4. doi: 10.1186/s13100-015-0035-7

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© Schmitt et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A HML-2 locus in human chromosome 5q15 once formed by L1-mediated retrotransposition of rec mRNA. (A) Multiple sequence alignments of relevant regions of the HERV-K(HML-2.HOM) proviral sequence (GenBank acc. no. AF074086; ref. [31]), a rec mRNA sequence (GenBank acc. no. X72790; ref. [8]), a recently described retrotransposed rec mRNA in human chromosome 2q32.1 [21], and the HML-2 locus in human chromosome 5q15 are shown, depicting target site duplications, rec-typical intron/exon boundaries and poly-A tails immediately upstream of the 3′TSD of the chromosome 2q32.1 and 5q15 loci. See ref. [21] for a more detailed description of the chromosome 2q32.1 locus. (B) A dot plot matrix comparison of the chromosome 5q15 locus sequence (reverse complemented) with the HERV-K(HML-2.HOM) reference sequence is shown with proviral regions indicated for the latter, likewise depicting the rec-typical proviral regions present for that HML-2 locus. (C) Presence of the HML-2 locus in the homologous regions of human chromosome 5q15 in the genomes of chimpanzee, gorilla, orangutan, gibbon, and lack in rhesus monkey (the homologous HML-2 locus also lacking in baboon is not shown). Marmosets, as new world monkeys, generally lack HERV-K(HML-2) homologous sequences. LTR, long terminal repeat; SA, splice acceptor; SD, splice donor; TSD, target site duplication.