Table 2.
Association of Fractures With Uric Acid
| Nonspine fractures |
Hip fractures |
|||||
|---|---|---|---|---|---|---|
| Uric acid (mg/dL) | Base model1 | MV2 | MV + eGFR | Base model | MV | MV + eGFR |
| Per SD increase | 0.82 (0.72–0.93) | 0.81 (0.71–0.93) | 0.82 (0.7–0.95) | 0.79 (0.57–1.09) | 0.78 (0.56–1.09) | 0.83 (0.56–1.24) |
| Quartiles of uric acid | ||||||
| Q1: 2.6 to 5.0 (ref) | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Q2: 5.1 to 5.8 | 0.85 (0.62–1.16) | 0.88 (0.64–1.21) | 0.88 (0.63–1.21) | 0.93 (0.46–1.86) | 0.99 (0.49–2.00) | 0.97 (0.47–2.01) |
| Q3: 5.9 to 6.6 | 0.78 (0.56–1.08) | 0.81 (0.58–1.13) | 0.82 (0.59–1.14) | 0.92 (0.47–1.81) | 0.97 (0.49–1.93) | 1.01 (0.51–1.99) |
| Q4: 6.7 to 13.6 | 0.60 (0.43–0.85) | 0.59 (0.41–0.84) | 0.61 (0.41–0.91) | 0.48 (0.21–1.09) | 0.44 (0.18–1.06) | 0.49 (0.18–1.33) |
| p for trend | 0.0038 | 0.0032 | 0.014 | 0.0883 | 0.069 | 0.213 |
| Q4 versus Q1, Q2, Q3 | 0.69 (0.52–0.93) | 0.66 (0.49–0.89) | 0.69 (0.49–0.96) | 0.5 (0.25–1.03) | 0.45 (0.21–0.97) | 0.49 (0.21–1.18) |
eGFR = estimated glomerular filtration rate.
1
Base model adjusted for age, race, clinic site, BMI, and total hip BMD for fracture models.
2
MV (multivariate) model adjusted for covariates in base model and vitamin D, PTH, PASE score, walking speed, and frailty status.