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. 2015 Mar 4;15:22. doi: 10.1186/s12883-015-0283-7

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© Potic et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Magnetic resonance imaging (MRI) study in the patient with 4H leukodystrophy. (a) T1W (T1-weighted) axial scan of the brain indicating hypomyelination; (b) T2W (T2-weighted) scan of the brain and T2W-hypointensity of the globi pallidi; (c) affection of the middle cerebellar peduncles:T2W scan; (d) T2W-hypointensity of the nucleus dentatus; (e) atrophy of the cerebellum, brainstem, corpus callosum and the adenohypophisis: sagittal T1W scan; (f) the small adenohypophysis: coronal T1W scan + contrast; (g) Magnetic resonance spectroscopy: decreased choline/creatine ratio in the lesions; (h) Diffusion tensor imaging of the brain supporting hypomyelination; (i, j) the unaffected spinal cord: T2W scans.