Table 5.

Pharmacokinetic parameter after oral administration of Qishe pill at a dose of 6.33 g•kg-1 to SD rats (mean ± SD, n = 6)

Parameters	SEA	SEI	FOR	ONO	5-O-M	AST-IV
t 1/2 (h)	22.72 ± 11.49	12.35 ± 10.3	51.24 ± 44.19	7.04 ± 3.7	42.79 ± 16.29	11.41 ± 12.51
C max (ng/ml)	53.71 ± 16.14	136.51 ± 45.24	9.39 ± 4.32	2.45 ± 1.51	0.14 ± 0.07	13.3 ± 5.42
T max (h)	0.22 ± 0.07	0.31 ± 0.16	0.22 ± 0.07	0.25 ± 0.00	0.25 ± 0.00	2.00 ± 2.25
AUC last(h*ng/ml)	606.87 ± 161.89	851.3 ± 251.31	38.1 ± 8.04	4.17 ± 1.53	1.13 ± 0.10	107.74 ± 65.65
AUC tot(h*ng/ml)	826.3 ± 229.51	900.76 ± 236.67	71.57 ± 26.49	4.89 ± 1.65	2.31 ± 0.41	129.75 ± 61.01
MRT (h)	36.54 ± 15.27	16.58 ± 6.89	70.4 ± 60.63	9.55 ± 4.04	65.96 ± 20.60	17.9 ± 17.38
CL (L/h/kg)	0.05 ± 0.01	0.02 ± 0.01	0.02 ± 0.00	0.12 ± 0.05	0.16 ± 0.03	0.06 ± 0.07
V z (L/kg)	1.41 ± 0.67	0.41 ± 0.33	0.98 ± 0.43	1.12 ± 0.83	9.38 ± 2.09	0.83 ± 0.94