Table 1.
Case | Sex | Age | Pathologic Stage |
Nodal and Metastatic Stage |
Fuhrman Grade |
Additional pathologic features |
Bone micro- metastasisa |
Histological verification of bone metastasisb |
Soft tissue metastasisc |
Patient outcome at 6 months |
---|---|---|---|---|---|---|---|---|---|---|
1 | F | 64 | T3a | NxMx | III | 23/31 | 8/14 | 17/31 | Metastastic disease (lung, renal, pancreatic) |
|
2 | M | 75 | T2a | NxMx | III/IV | Rhabdoid, papillary |
0/4 | ns | 1/4 | Metastatic disease (lung) |
3 | M | 62 | T3a | NxMx | III | 0/2 | ns | 0/2 | No recurrence | |
4 | M | 68 | T3a | NxMx | Chromophobe | Papillary | 3/4 | ns | 0/4 | Multiple bone metastases |
5 | M | 91 | T3a | NxM1 | III | 0/7 | ns | 0/7 | Not known | |
6 | F | 59 | T3a | NxM1d | IV | Rhabdoid | 0/10 | 0/3 | 0/10 | Not known |
7 | M | 42 | T3a | NxMx | III | 1/7 | 0/2 | 0/7 | No recurrence |
ns not studied
Bone micrometastasis shows the number of mice that had bone metastasis/number of mice studied, detected by human-specific qRT-PCR
Histological verification of bone metastasis shows the number of mice with histologically confirmed metastasis/mice studied, detected by H&E and human-specific immunohistochemistry (human-specific Ku70 and/or CAIX-staining). In case 1, bones from 18 different TSG-bearing mice were studied and 14 of those were from mice that had bone micrometastases detected by qRT-PCR. Eight metastases of these were confirmed histologically
Soft tissue metastasis shows the number of mice that had soft tissue metastasis (liver or lung)/number of mice studied at sacrifice
This patient underwent surgical removal of brain and bone metastases, followed by two cycles of Sunitinib, prior to nephrectomy and implantation of tissue into mice