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. Author manuscript; available in PMC: 2015 Mar 6.
Published in final edited form as: Nat Rev Mol Cell Biol. 2011 Nov 23;12(12):827–841. doi: 10.1038/nrm3228

Fig 5. Inhibition or poisoning points for type II topoisomerases.

Fig 5

Detailed schematic of the type II topoisomerase reaction cycle, showing all of the points where exogenous agents can disrupt function. During its reaction cycle, the topoisomerase initially binds one duplex DNA segment. Following binding, the topoisomerase can then associate with a second duplex DNA segment. ATP binding stimulates cleavage and opening of the first DNA, and passage of the second through the opening. Agents have been identified that interfere with: (1) DNA binding, (2) ATP binding, (3) DNA cleavage, (4) strand passage, (5) religation, and (6) product release. Only a partial list of all inhibitors and poisons is shown.