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. 2015 Mar 5;13:80. doi: 10.1186/s12967-015-0437-9

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© Bissa et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Tumor growth after therapeutic immunization. Mice were challenged with TC-1* cells and immunized twice at day 3 and 10 p.c. Immunization was performed with DNA/DNA (G1), DNA/FP (G2), and FP/FP (G3) recombinants expressing the E6_F47R. The mice of group 4 were mock vaccinated. Tumor growth was monitored by visual inspection and palpation. Animals were euthanized when the tumors reached a 4-cm³ volume.