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. 2015 Jan 23;14:7. doi: 10.1186/s12943-014-0283-z

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© Fischer et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Stable expression of miR-17 downregulates RUNX1-regulated miRNAs of myeloid differentiation. (A-B) U937 clones stably expressing miR-17 (A), RUNX1-MTG8, or CBFB-MYH11 (B) display block of PMA-induced myeloid differentiation (assessed by CD11b cytofluorimetric analysis) relative to their cognate control clones. (C) Consistently, U937^miR-17, U937^RUNX1-MTG8, and U937^CBFB-MYH11 clones also display downregulation of miR-223 (assessed by qRT-PCR).