Fig 5. Continuous real-time VSMC E-modulus recordings following ADO or NO.
(A) VSMC E-modulus immediately reduced after addition of ADO (10−4 M) as shown in a representative example. (B) Group average of VSMC E-modulus after addition of ADO (n = 10) in cell bath. (C) Average E-modulus summed across all time points for the group of VSMCs before and after ADO (n = 10, *P<0.05). (D) A representative single cell measurement shows decrease in VSMC E-modulus following addition of NO to the cell bath. (E) Alteration in group average of VSMC E-modulus before and after addition of NO (n = 10). (F) Average E-modulus summed for all time points before and after addition of NO showed a significant decrease in VSMC E-modulus (n = 10, *P<0.05). Data were presented as mean ± SEM.