Fig 9. Proposed mechanism of action of MINK in the EV71 replication cycle.

EV71 infection stimulates MINK activation which in turn triggers the phosphorylation of p38 MAPK downstream. The phosphorylation of p38 MAPK triggers a kinase cascade which results in the cytoplasmic relocalisation of hnRNP A1. hnRNP A1 binds to the viral IRES and promotes the recruitment of ribosomes at the IRES at the 5’ untranslated region (UTR) of EV71 genome, stimulating the IRES-mediated viral protein translation.