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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Endocr Relat Cancer. 2015 Jan 26;22(2):R69–R86. doi: 10.1530/ERC-14-0411

Figure 1. Potential mechanisms for POPs in the promotion of breast cancer.

Figure 1

Obesity-associated endocrine and metabolic mediators are suspected to play a role in oncogenesis by modifying both systemic nutrient metabolism and the nutrients available locally in the supportive stromal tissue. Excessive adipose in obese women also serve as storage depots for POPs obtained from dietary sources. The accumulated POPs stimulate additional adipocyte proliferation and recruitment of immune cells, leading to an inflammatory microenvironment. Collectively, these factors may promote breast cancer development and/or direct cancer cell phenotypes.