Table 2.

Results of genetic association analysis of TB phenotype (SNPs with nominal p-values <0.05)

SNP	Gene	Location	OR (95% CI)	p	Best Model
rs2569254	IL12B	intron	1.75 (1.05, 2.90)	3.1E-02	Dom
rs5744229	IL18	intron	1.63 (1.05, 2.51)	2.8E-02	Dom
rs1143643	IL1B	intron	1.99 (1.43, 2.76)	4.2E-05*	Dom
rs1143633	IL1B	intron	1.59 (1.13, 2.24)	7.7E-03	Dom
rs2243270	IL4	intron	0.67 (0.51, 0.90)	6.9E-03	Dom
rs2243274	IL4	intron	0.72 (0.53, 0.96)	2.8E-02	Dom
rs2243290	IL4	intron	0.64 (0.45, 0.91)	1.3E-02	Dom
rs17159043	NOD1	intron	1.56 (1.11, 2.17)	9.4E-03	Dom
rs2970499	NOD1	intron	1.91 (1.17, 3.13)	9.8E-03	Dom
rs13062	SLC11A1	flanking 3’ UTR	1.48 (1.05, 2.09)	2.6E-02	Dom
rs2550936	SLC6A3	intron	1.35 (1.04, 1.76)	2.4E-02	Add
rs256946	TICAM2	flanking 5’ UTR	0.67 (0.46, 0.99)	4.6E-02	Dom
rs419939	TICAM2	flanking 5’ UTR	0.79 (0.63, 0.99)	4.4E-02	Add
rs746566	TICAM2	flanking 5’ UTR	1.42 (1.22, 1.65)	3.6E-06*	Add
rs4624663	TLR1	3’ UTR	1.52 (1.02, 2.27)	4.2E-02	Dom
rs11938228	TLR2	flanking 5’ UTR	0.66 (0.44, 0.99)	4.4E-02	Dom
rs5743818	TLR6	Coding A644A	0.52 (0.28, 0.96)	3.8E-02	Add
rs4963062	TOLLIP	intron	1.44 (1.05, 1.98)	2.4E-02	Dom
rs5743867	TOLLIP	intron	1.52 (1.12, 2.05)	6.8E-03	Dom

^*Experiment-wide significant (p < 2 × 10⁻⁴)