Table 3.
Genotype x age interaction analysis of TB.
| Children* | Adults* | Interaction | ||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Gene | Location | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p |
| rs2834210 | IFNGR2 | intron | 1.44 (0.94, 2.21) | 0.091 | 0.81 (0.64, 1.04) | 0.10 | 0.56 (0.35, 0.92) | 0.023 |
| rs2834214 | IFNGR2 | intron | 1.38 (0.84, 2.26) | 0.20 | 0.77 (0.60, 0.99) | 0.045 | 0.56 (0.32, 0.98) | 0.041 |
| rs2834215 | IFNGR2 | intron | 1.34 (0.82, 2.20) | 0.24 | 0.74 (0.58, 0.96) | 0.021 | 0.55 (0.32, 0.97) | 0.037 |
| rs9808685 | IFNGR2 | intron | 0.66 (0.43, 1.01) | 0.057 | 1.20 (0.95, 1.52) | 0.13 | 1.83 (1.12, 2.98) | 0.016 |
| rs3212220 | IL12B | intron | 0.49 (0.28, 0.87) | 0.014 | 0.99 (0.77, 1.28) | 0.96 | 2.02 (1.08, 3.78) | 0.028 |
| rs6894567 | IL12B | intron | 0.50 (0.30, 0.85) | 0.0096 | 0.93 (0.72, 1.19) | 0.56 | 1.84 (1.03, 3.29) | 0.039 |
| rs17887176 | IL12RB1 | coding P47S | 0.36 (0.11, 1.20) | 0.096 | 1.40 (0.87, 2.25) | 0.16 | 3.9 (1.14, 13.38) | 0.030 |
| rs375947 | IL12RB1 | coding M365T | 0.80 (0.48, 1.33) | 0.39 | 1.51 (1.15, 1.99) | 0.0028 | 1.90 (1.06, 3.39) | 0.031 |
| rs3761041 | IL12RB1 | intron | 0.72 (0.38, 1.37) | 0.32 | 1.54 (1.11, 2.15) | 0.010 | 2.13 (1.05, 4.32) | 0.036 |
| rs12091150 | IL12RB2 | intron | 0.59 (0.35, 1.01) | 0.056 | 1.14 (0.88, 1.47) | 0.32 | 1.92 (1.06, 3.46) | 0.031 |
| rs2307147 | IL12RB2 | coding D26D | 0.59 (0.35, 1.00) | 0.051 | 1.13 (0.88, 1.46) | 0.34 | 1.92 (1.07, 3.47) | 0.030 |
| rs2043055 | IL18 | intron | 0.55 (0.34, 0.88) | 0.013 | 1.22 (0.97, 1.52) | 0.089 | 2.21 (1.31, 3.73) | 0.0029 |
| rs360714 | IL18 | intron | 0.49 (0.27, 0.88) | 0.018 | 1.11 (0.83, 1.48) | 0.48 | 2.27 (1.18, 4.34) | 0.014 |
| rs360722 | IL18 | intron | 0.67 (0.41, 1.08) | 0.10 | 1.16 (0.91, 1.48) | 0.22 | 1.75 (1.03, 2.96) | 0.038 |
| rs3882891 | IL18 | intron | 1.95 (1.19, 3.20) | 0.0084 | 0.87 (0.70, 1.10) | 0.24 | 0.45 (0.26, 0.77) | 0.0037 |
| rs5744280 | IL18 | intron | 1.84 (1.12, 3.04) | 0.017 | 0.85 (0.66, 1.08) | 0.19 | 0.46 (0.26, 0.80) | 0.0058 |
| rs3783550 | IL1A | intron | 0.40 (0.19, 0.82) | 0.012 | 1.01 (0.74, 1.39) | 0.93 | 2.55 (1.15, 5.65) | 0.021 |
| rs3136558 | IL1B | intron | 1.86 (1.14, 3.03) | 0.014 | 0.94 (0.68, 1.30) | 0.71 | 0.51 (0.28, 0.92) | 0.025 |
| rs17313265 | NOD2 | intron | 0.70 (0.28, 1.75) | 0.45 | 1.98 (1.23, 3.19) | 0.0052 | 2.82 (1.05, 7.53) | 0.039 |
| rs6349 | SLC6A3 | coding A577A | 0.36 (0.14, 0.97) | 0.044 | 1.19 (0.83, 1.71) | 0.35 | 3.28 (1.14, 9.40) | 0.027 |
| rs11904548 | STAT1 | intron | 1.89 (1.05, 3.43) | 0.035 | 0.90 (0.63, 1.29) | 0.56 | 0.47 (0.24, 0.96) | 0.037 |
| rs13029247 | STAT1 | intron | 0.59 (0.32, 1.08) | 0.087 | 1.29 (0.95, 1.76) | 0.11 | 2.19 (1.13, 4.24) | 0.021 |
| rs16833157 | STAT1 | intron | 1.74 (0.94, 3.21) | 0.078 | 0.75 (0.52, 1.09) | 0.13 | 0.43 (0.21, 0.90) | 0.024 |
| rs1914408 | STAT1 | intron | 0.40 (0.18, 0.87) | 0.021 | 1.19 (0.90, 1.58) | 0.22 | 2.98 (1.34, 6.62) | 0.0074 |
| rs2066804 | STAT1 | intron | 0.47 (0.23, 0.94) | 0.032 | 1.28 (0.97, 1.70) | 0.08 | 2.74 (1.33, 5.63) | 0.006 |
| rs2280235 | STAT1 | intron | 0.39 (0.18, 0.84) | 0.017 | 1.22 (0.92, 1.61) | 0.17 | 3.14 (1.42, 6.91) | 0.0046 |
| rs3771300 | STAT1 | intron | 1.62 (1.05, 2.49) | 0.028 | 0.84 (0.64, 1.10) | 0.20 | 0.52 (0.32, 0.85) | 0.009 |
| rs7576984 | STAT1 | intron | 1.70 (0.98, 2.98) | 0.061 | 0.74 (0.52, 1.04) | 0.086 | 0.43 (0.22, 0.84) | 0.014 |
| rs11466716 | TICAM1 | flanking 5’ UTR | 0.42 (0.20, 0.88) | 0.022 | 0.99 (0.72, 1.37) | 0.95 | 2.37 (1.06, 5.29) | 0.035 |
| rs7864330 | TLR4 | intron | 2.14 (1.17, 3.92) | 0.014 | 0.89 (0.61, 1.31) | 0.56 | 0.42 (0.21, 0.84) | 0.015 |
| rs5743809 | TLR6 | coding L194P | 3.47 (1.57, 7.66) | 0.0020 | 1.12 (0.80, 1.58) | 0.50 | 0.32 (0.14, 0.75) | 0.0086 |
| rs5743812 | TLR6 | coding T287T | 3.59 (1.62, 7.92) | 0.0016 | 1.15 (0.81, 1.64) | 0.44 | 0.32 (0.14, 0.75) | 0.0085 |
| rs5743832 | TLR6 | flanking 3’ UTR | 4.23 (1.84, 9.76) | 0.00071 | 1.10 (0.78, 1.56) | 0.59 | 0.26 (0.11, 0.63) | 0.0027 |
*
Odds ratios for children and adults were derived from the models containing the age x genotype interaction term, and are not interpretable independently from the interaction term.