Table 5.
Genotype x age interaction analysis of RSTR
| Children* | Adults* | Interaction | ||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Gene | Location | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p |
| rs1059293 | IFNGR2 | 3UTR | 0.76 (0.44, 1.33) | 0.34 | 1.92 (0.93, 3.96) | 0.079 | 2.51 (1.04, 6.08) | 0.041 |
| rs2284555 | IFNGR2 | intron | 0.76 (0.43, 1.34) | 0.34 | 1.95 (0.95, 4.00) | 0.070 | 2.56 (1.06, 6.18) | 0.037 |
| rs365179 | IL12RB1 | intron | 0.66 (0.40, 1.09) | 0.10 | 1.70 (0.91, 3.18) | 0.098 | 2.59 (1.21, 5.52) | 0.014 |
| rs375947 | IL12RB1 | coding M365T | 0.55 (0.33, 0.92) | 0.023 | 1.59 (0.86, 2.96) | 0.14 | 2.89 (1.36, 6.15) | 0.006 |
| rs376008 | IL12RB1 | intron | 0.69 (0.43, 1.10) | 0.12 | 1.85 (0.94, 3.64) | 0.077 | 2.69 (1.19, 6.06) | 0.017 |
| rs382634 | IL12RB1 | intron | 0.68 (0.42, 1.10) | 0.12 | 1.89 (0.97, 3.71) | 0.063 | 2.79 (1.24, 6.28) | 0.013 |
| rs429774 | IL12RB1 | intron | 0.70 (0.44, 1.12) | 0.14 | 2.00 (1.05, 3.80) | 0.034 | 2.85 (1.31, 6.18) | 0.0082 |
| rs845375 | IL12RB1 | intron | 0.72 (0.40, 1.28) | 0.26 | 1.76 (0.84, 3.66) | 0.13 | 2.44 (1.05, 5.66) | 0.038 |
| rs11209052 | IL12RB2 | intron | 2.22 (1.27, 3.88) | 0.005 | 0.30 (0.05, 1.77) | 0.18 | 0.14 (0.02, 0.85) | 0.033 |
| rs12091150 | IL12RB2 | intron | 1.49 (0.95, 2.34) | 0.085 | 0.46 (0.21, 1.01) | 0.053 | 0.31 (0.13, 0.76) | 0.011 |
| rs2307147 | IL12RB2 | coding D26D | 1.52 (0.97, 2.39) | 0.069 | 0.46 (0.21, 1.02) | 0.055 | 0.30 (0.12, 0.74) | 0.0094 |
| rs3882891 | IL18 | intron | 0.89 (0.60, 1.31) | 0.55 | 1.86 (0.98, 3.52) | 0.057 | 2.10 (1.04, 4.26) | 0.040 |
| rs3783587 | IL1A | intron | 0.74 (0.21, 2.58) | 0.64 | 3.22 (1.17, 8.84) | 0.023 | 4.33 (1.14, 16.52) | 0.032 |
| rs28363167 | SLC6A3 | 3UTR | 0.35 (0.06, 1.97) | 0.23 | 3.05 (1.01, 9.18) | 0.047 | 8.82 (1.33, 58.63) | 0.024 |
| rs464049 | SLC6A3 | intron | 1.46 (0.96, 2.23) | 0.08 | 0.55 (0.22, 1.35) | 0.19 | 0.38 (0.14, 1.00) | 0.049 |
| rs2280235 | STAT1 | intron | 0.88 (0.58, 1.34) | 0.55 | 1.80 (0.94, 3.47) | 0.078 | 2.05 (1.01, 4.18) | 0.048 |
| rs10983756 | TLR4 | intron | 0.59 (0.23, 1.52) | 0.28 | 3.39 (1.43, 8.02) | 0.0054 | 5.72 (1.59, 20.55) | 0.0076 |
| rs12344353 | TLR4 | intron | 0.57 (0.30, 1.10) | 0.096 | 1.67 (0.74, 3.78) | 0.22 | 2.93 (1.06, 8.05) | 0.037 |
| rs5030717 | TLR4 | intron | 1.31 (0.81, 2.13) | 0.27 | 0.48 (0.19, 1.19) | 0.11 | 0.37 (0.14, 0.99) | 0.049 |
| rs5743808 | TLR6 | coding I120T | 0.77 (0.41, 1.42) | 0.40 | 2.00 (1.13, 3.56) | 0.018 | 2.61 (1.18, 5.79) | 0.018 |
*
Odds ratios for children and adults were derived from the models containing the age x genotype interaction term, and are not interpretable independently from the interaction term.