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. Author manuscript; available in PMC: 2016 Feb 4.
Published in final edited form as: Neuron. 2015 Jan 22;85(3):534–548. doi: 10.1016/j.neuron.2014.12.068

Figure 3. Transcriptome analysis of brains from APP/PS1 mice deficient in Il10.

Figure 3

(A) Scatterplot of the average expression per gene (RPKM) of APP/PS1+Il10+/+ (n=5) plotted against APP/PS1+Il10+/− (n=5) or APP/PS1+Il10−/− mice (n=5). The blue line represents a 2-fold change.

(B) A heat map of k-means cluster analysis of log2 transformed expression (RPKM) is shown for 117 genes with 2-fold or greater change. Genes that are immune-related (as reported by the KEGG database) are indicated in orange.

(C) A table of immune- and inflammation-related genes identified from the heat map with log2 (fold change) of APP/PS1+Il10+/+ versus APP/PS1+Il10−/− mice is shown, and false discovery rate is calculated by the edgeR package in Bioconductor. See also Figure S3.