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. Author manuscript; available in PMC: 2016 Feb 4.
Published in final edited form as: Neuron. 2015 Jan 22;85(3):534–548. doi: 10.1016/j.neuron.2014.12.068

Figure 6. Il10 deficiency partially restores cognitive function in APP/PS1 mice.

Figure 6

(A) Spontaneous activity was tested in the open field over a 30 min period. Bars represent fine movements of the mice.

(B) Evaluation of episodic memory in the novel object recognition test after 1 h of retention. Plots represent the recognition index.

(C, D) Determination of spontaneous alternation in the Y-maze. Bars represent number of arms entered (C) or percent spontaneous alternation (D).

Data are represented as mean ± SEM for Il10+/+ (n=5–6), Il10+/− (n=15–16), Il10−/− (n=8–11), APP/PS1+Il10+/+ (n=8–10), APP/PS1+Il10+/− (n=8–9) and APP/PS1+Il10−/− mice (n=7); Compared to APP/PS1 groups: †p≤0.1, *p≤0.05, ****p<0.0001. See also Figure S5.