Table 1.

Clinical course, indicating infections, autoimmune manifestations, treatments (in italics) and times at which samples were obtained for study

Age	Clinical manifestation
1–3 months	Bloody stool, erythroderma (later biopsy showing lymphocyte infiltration)
9 months	Poor growth (<5 % weight, 5 % height), hospitalization for prolonged fever, presumed bacterial infections responding to systemic antibiotics; S. aureus superinfection of rash
10 months	IgG infusions instituted
13 months	Thrush, candida esophagitis
	Continuous antibiotic prophylaxis started
	DNA isolated from PBMCs, later used for whole exome sequencing
15 months	Persistent CMV >3,000 copies by PCR from blood, lung washings despite gancyclovir and foscarnet treatment; ground glass pneumonitis; self limited RSV bronchiolitis; diarrhea with C. difficile
18 months	Hematopoietic cell transplant from 9/10 HLA matched unrelated donor
19 months	Rash resolved, donor T cells detected; no graft vs. host disease
23 months	Graft vs. host disease prophylaxis discontinued
	Lymphocyte proliferation to PHA >50 % normal, persistent CMV viremia 1,500 copies
	PBMCs isolated, separated into autologous patient and donor populations for in vitro functional studies
28 months	Antibiotic prophylaxis discontinued
30 months	Donor T cell infusion for persistent CMV viremia
	CMV viremia resolved, gaining weight (25 % for age)
6 years	Donor B cell function detected with normal IgM and IgA, positive IgM isohemagglutinin