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Safety outcomes, subgroup analyses
| All studies |
Alteplase |
Tenecteplase |
Other thrombolytics |
Group difference |
|||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | I2 (%) | OR (95% CI) | OR (95% CI) | OR (95% CI) | P-value | |
| Major bleeding | 2.91 (1.95 to 4.36) | <0.001 | 25 | 1.07 (0.43 to 2.62) | 5.02 (2.72 to 9.26) | 2.16 (1.03 to 4.54) | 0.02 |
| Fatal/intracranial haemorrhage | 3.18 (1.25 to 8.11) | 0.008 | 0 | 1.09 (0.27 to 4.40) | 7.32 (1.64 to 32.63) | NA | 0.07 |
