Table 3.

Sensitivity analysis of significantly associated variants

	Cases vs. Controls		Cases vs. EUR †
Variant	OR (95% CI # ), unadjusted model	OR (95% CI # ), adjusted model*	OR (95% CI # ), unadjusted model
c.5682G > C	0.30 (0.09-0.85)	0.05 (0.00 - 1.00)	0.43 (0.16-0.94)
c.5814A > G	0.16 (0.03-0.63)	0.01 (0.00 - 0.27)	0.32 (0.08-0.91)
c.5844A > G	0.16 (0.03-0.63)	0.01 (0.00 - 0.27)	0.29 (0.07-0.80)

*Adjusted jointly for age, gender, treatment duration and daily dose per ideal bodyweight.

^†Patients treated with CQ and affected with toxic maculopathy were compared to data from 267 European individuals obtained from the 1000 Genomes Project.

^#Confidence intervals.