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. 2015 Mar 4;16:72. doi: 10.1186/s13063-015-0574-8

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© Connor et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Mean total sample size enrolled (left panel) and probability of trial success (right panel). SHINE is plotted with a circle and the Goldilocks is plotted with an x. Heavy line represents a control success rate of 25%, medium line represents a control success rate of 30%, and light line represents a control rate of 35%. Dashed line on the right panel shows 80% power for reference.