Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Probability of increasing the maximum sample size (left panel) and mean number of patients added (right panel). SHINE is plotted with a circle (Goldilocks design does not include sample size re-estimation). Heavy line represents a control success rate of 25%, medium line represents a control success rate of 30%, and light line represents a control rate of 35%.
