Table 3.
| A Univariate and multivariable hazard ratios predicting biochemical recurrence, metastasis and prostate cancer-specific mortality. | ||||||
|---|---|---|---|---|---|---|
| Univariate | Multivariable | |||||
| HR | 95% CI | P | HR | 95% CI | P | |
| Biochemical recurrence | ||||||
| Risk category | ||||||
| Low (referent) | 1 | – | – | 1 | – | – |
| PII | 3.03 | 2.49, 3.69 | <0.001 | 2.85 | 2.33, 3.47 | <0.001 |
| Intermediate except PII | 4.26 | 3.74, 4.85 | <0.001 | 4.20 | 3.86, 4.78 | <0.001 |
| PIH | 5.95 | 4.21, 8.42 | <0.001 | 5.32 | 3.75, 7.54 | <0.001 |
| High except PIH | 10.61 | 9.18, 12.26 | <0.001 | 10.05 | 8.68, 11.63 | <0.001 |
| Age | 1.02 | 1.01, 1.03 | <0.001 | 1.00 | 0.99, 1.01 | 0.402 |
| Black race | 1.70 | 1.43, 2.01 | <0.001 | 1.56 | 1.32, 1.85 | <0.001 |
| Year of surgery | 0.96 | 0.95, 0.97 | <0.001 | 0.98 | 0.97, 0.99 | <0.001 |
| Metastasis | ||||||
| Risk category | ||||||
| Low (referent) | 1 | – | – | 1 | – | – |
| PII | 3.17 | 1.87, 5.38 | <0.001 | 2.99 | 1.76, 5.08 | <0.001 |
| Intermediate except PII | 7.66 | 5.45, 10.78 | <0.001 | 7.47 | 5.30, 10.53 | <0.001 |
| PIH | 6.59 | 2.81, 15.47 | <0.001 | 6.14 | 2.61, 14.46 | <0.001 |
| High except PIH | 22.75 | 16.09, 32.18 | <0.001 | 21.33 | 15.01, 30.31 | <0.001 |
| Age | 1.03 | 1.01, 1.05 | 0.003 | 1.01 | 0.99, 1.02 | 0.526 |
| Black race | 0.96 | 0.58, 1.59 | 0.883 | 0.86 | 0.52, 1.42 | 0.544 |
| Year of surgery | 0.93 | 0.90, 0.96 | <0.001 | 0.97 | 0.94, 0.99 | 0.016 |
| Prostate cancer-specific mortality | ||||||
| Risk category | ||||||
| Low (referent) | 1 | – | – | 1 | – | – |
| PII | 3.51 | 1.77, 6.98 | <0.001 | 3.32 | 1.67, 6.61 | 0.001 |
| Intermediate except PII | 8.28 | 5.15, 13.30 | <0.001 | 7.98 | 4.95, 12.86 | <0.001 |
| PIH | 7.64 | 2.63, 22.19 | <0.001 | 7.07 | 2.43, 20.59 | <0.001 |
| High except PIH | 26.00 | 16.28, 41.53 | <0.001 | 23.92 | 14.84, 38.56 | <0.001 |
| Age | 1.02 | 1.00, 1.05 | 0.040 | 1.00 | 0.98, 1.02 | 0.916 |
| Black race | 1.23 | 0.67, 2.26 | 0.504 | 1.04 | 0.57, 1.91 | 0.900 |
| Year of surgery | 0.89 | 0.85, 0.93 | <0.001 | 0.96 | 0.92, 1.00 | 0.058 |
| B Univariate and multivariable hazard ratios predicting biochemical recurrence and metastasis among the cohort of men with PSA-incongruent intermediate risk prostate cancer. | ||||||
|---|---|---|---|---|---|---|
| Univariate | Multivariable | |||||
| HR | 95% CI | P | HR | 95% CI | P | |
| Biochemical recurrence | ||||||
| PII, PSAD ≥0.15 ng/mL/g | 3.79 | 1.85, 7.76 | <0.001 | 4.04 | 1.96,8.31 | <0.001 |
| Age | 1.02 | 0.99, 1.05 | 0.108 | 1.04 | 1.01,1.07 | 0.009 |
| Black race | 2.23 | 1.35, 3.69 | 0.002 | 2.35 | 1.42,3.91 | 0.001 |
| Year of surgery | 0.96 | 0.92, 1.00 | 0.066 | 0.96 | 0.92,1.01 | 0.106 |
| Metastasis | ||||||
| PII, PSAD ≥0.15 ng/mL/g | 4.33 | 0.58, 32.44 | 0.154 | 4.32 | 0.56,33.23 | 0.159 |
| Age | 1.02 | 0.95, 1.10 | 0.561 | 1.04 | 0.96,1.12 | 0.326 |
| Black race | 2.86 | 0.83, 9.87 | 0.096 | 2.82 | 0.81,9.78 | 0.102 |
| Year of surgery | 0.92 | 0.79, 1.07 | 0.305 | 0.94 | 0.81,1.10 | 0.423 |
PII, PSA-incongruent intermediate risk; PIH, PSA-incongruent high risk; HR, hazard ratio.
PII, PSA-incongruent intermediate risk; PIH, PSA-incongruent high risk; PSAD, PSA density; HR, hazard ratio.