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Schematic illustrating study design. Note: FF/VI 100/25 μg and fluticasone furoate (FF)/vilanterol (VI) 200/25 μg are nominal doses, representing emitted doses of FF and VI via the dry powder inhaler of 92/22 μg and 184/22 μg, respectively. *All inhaled dosing once daily in the evening. All oral capsules taken in the morning on the last 7 days of study only. ‡24-h serum cortisol and urine cortisol sampling. §Pharmacokinetic sampling.
