Table 3.
Day 42 0–24-h plasma concentration of FF and VI geometric mean (pharmacokinetics population)
| Parameter geometric mean (95% CI) | Cmax [pg/mL] | Median tmax [h] (range) | AUC(0–t) [pg.h/mL] |
|---|---|---|---|
| FF | |||
| 100/25 μg | 19.4 (16.8–22.4) | 0.50 (0.03–8.97) | 58.8 (37.7–91.8) |
| 200/25 μg | 33.0 (28.6–38.1) | 0.50 (0.07–4.00) | 221.7 (152.7–321.9) |
| VI | |||
| 100/25 μg | 71.1 (54.2–93.2) | 0.083 (0.00–2.00) | 22.6 (16.0–32.1) |
| 200/25 μg | 89.9 (71.7–112.8) | 0.083 (0.00–16.00) | 28.9 (20.0–41.6) |
AUC(0–t), area under the curve between time 0 and t; CI, confidence interval; Cmax, maximum plasma concentration; FF, fluticasone furoate; tmax, time taken to reach Cmax; VI, vilanterol.