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. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: Dev Biol. 2015 Jan 21;399(2):283–295. doi: 10.1016/j.ydbio.2015.01.004

Figure 6.

Figure 6

RhoGAP68F and Fas3 interact genetically to affect epithelial morphology. (A) Expression of GFP in the Ptc domain had no effect on epithelial morphology. In contrast, (B) depletion of Rab4, or (C) Fas3, or (F) overexpression of Flag-RhoGAP68F caused bending of the epithelium in the Ptc domain. (D) Depletion of RhoGAP68F in the Ptc domain had no affect on epithelial morphology. (E) Strikingly, depletion both Fas3 and RhoGAP68F suppressed the bending of the epithelium promoted by depletion of Fas3 alone. This result suggests that RhoGAP68F affects epithelial morphology at least in part through the regulation of Fas3 levels and dynamics. 20 discs were examined per genotype; representative examples are shown.