Table 1.

Renal Developmental Control Genes Suppressed in Pax2 Mutants

Gene	Expression	Mutant Phenotype	Reference
BMP7	MM, ND, UB	Dysplasia, arrested development	(Dudley et al., 1995)
Eya1	MM	Agenesis, absence of UB outgrowth	(Xu et al., 1999)
Gata3	ND, UB	Ectopic UB, kidney dysplasia	(Grote et al., 2006)
Gdnf	MM	Agenesis due to lack of UB growth	(Moore et al., 1996; Sanchez et al., 1996)
Hnf4a	SSB, PT		(Heliot et al., 2013)
Irx1	SSB	Defects in Xenopus pronephros	(Alarcon et al., 2008)
Irx3	CS	Defects in Xenopus pronephros	(Reggiani et al., 2007)
Lhx1	ND, UB, CS	Agenesis due to ND defects	(Tsang et al., 2000)
Npnt	UB	Agenesis or hypoplasia	(Linton et al., 2007)
Ret	ND, UB	Agenesis due to lack of UB outgrowth	(Schuchardt et al., 1996)
Sal1	MM, RV	Agenesis due to defect in UB	(Nishinakamura et al., 2001)
Six2	CM	Depletion of progenitor cells, dysplasia	(Self et al., 2006)
Vsnl1	UB tips		(Ola et al., 2011)

MM, metanephric mesenchyme; ND, nephric duct; UB, ureteric bud; CM, cap mesenchyme; RV, renal vesicle; Cs, comma shaped body; SSB, s-shaped body.