Table 2.
TOPPGENE Analyses of Pax2 Target Genes
| Upregulated Genes in Pax2 Mutants | |||
|---|---|---|---|
| Co-Expression Atlas | Source | p Value | No. (input/annotated) |
| E13.5 testis, interstitial | Gudmap | 8.2E-78 | 105/778 |
| E13.5 ovary, mesenchyme | Gudmap | 1.6E-56 | 88/798 |
| E11.5 female gonad, mesenchyme | Gudmap | 3.0E-55 | 69/424 |
| E11.5 male gonad, mesenchyme | Gudmap | 3.9E-55 | 88/828 |
| Adult kidney, renal capsule | Gudmap | 2.5E-38 | 70/780 |
| E15.5 kidney, pelvic mesenchyme | Gudmap | 3.3E-36 | 47/305 |
| E15.5 kidney, peripheral blastema | Gudmap | 4.0E-34 | 67/819 |
| E8.5 paraxial mesoderm | Facebase | 2.9E-32 | 70/970 |
| Gene Ontology, Biological Processes | |||
| Mesenchymal development | GO:0060484 | 2.4E-14 | 22/179 |
| Mesenchyme cell differentiation | GO:0048762 | 1.1E-8 | 18/152 |
| Epithelial to mesenchyme transition | GO:0001837 | 4.4E-7 | 10/84 |
| Downregulated Genes in Pax2 Mutants | |||
|---|---|---|---|
| Co-Expression Atlas | Source | p Value | No. (input/annotated) |
| E11.5 kidney, ureteric bud | Gudmap | 4.6E-75 | 92/813 |
| E15.5 kidney, cortical col. duct | Gudmap | 1.0E-59 | 79/775 |
| P4 kidney, cap mesench., renal vesicle | Gudmap | 1.9E-41 | 64/785 |
| E15.5 kidney, S-shaped body | Gudmap | 2.4E-33 | 44/406 |
| E15.5 kidney, prox. tubules | Gudmap | 1.2E-31 | 54/759 |
| Gene Ontology, Biological Processes | |||
| Renal development | GO:0001656 | 3.9E-10 | 12/94 |
| Ureteric bud development | GO:0001657 | 2.5E-9 | 12/110 |
| Nephron development | GO:0072006 | 1.1E-7 | 11/100 |