Figure 3.

Ehrlich ascites carcinoma inhibition (a) and survival time (b) in animals treated with juglone, Q7, or Q9 at 1 mg/kg alone or in combination with ascorbate (Asc) at 100 mg/kg. Doxorubicin was administered at 1.2 mg/kg for the positive control. Lipid peroxidation (c), DNA damage (d), and phosphorylated proteins Akt (pAkt) and H2AX (γH2AX) in ascitic cells from mice (e). (∗∗) and (∗∗∗) denote difference at P < 0.01 and P < 0.001 compared to the negative control or between indicated treatments.