Table 3.
HPV16 L1 sequence variations at the genome and protein level and the putative biological function affected.
| Genome position | Variation | AA changed | Protein position | Number of isolates | Biological function |
|---|---|---|---|---|---|
| 5862 | C/T | H102Y | β-C | 5/14 | MHC Class-I/MHC Class-II |
| 5909 | T/C | — | 5/14 | ||
| 5981 | G/A | — | 1/14 | ||
| 6023 | A/T | — | 1/14 | ||
| 6163 | C/A | T202N | EF-loop | 5/14 | B-cell/MHC Class-I |
| 6176 | A/C | N207T | EF-loop | 2/14 | B-cell/MHC Class-I/MHC Class-II |
| 6240 | C/G | H228D | EF-loop | 14/14 | B-cell/MHC Class-I |
| 6245 | T/C | — | 5/14 | ||
| 6300 | A/C | — | 1/14 | ||
| 6315 | A/G | — | 4/14 | ||
| 6436 | A/G | T292A | FG-loop | 5/14 | MHC Class-I/MHC Class-II |
| 6484 | T/C | — | 1/14 | ||
| 6561 | C/T | S308P | 5/14 | ||
| 6570 | T/G | — | 1/14 | ||
| 6697 | A/C | T379P | HI-loop | 5/14 | B-cell/MHC Class-I |
| 6723 | G/A | — | 5/14 | ||
| 6805 | A/T | T415S | h2 | 1/14 | MHC Class-I/MHC Class-II/VLP formation |
| 6856 | C/T | — | 5/14 | ||
| 6867 | C/T | — | 5/14 | ||
| 6903 | Ins ATC | Ins T and S 448 | h4 | 14/14 | MHC Class-I/ |
| 6955 | Del GAT | Del D 465 | h4-β-J | MHC Class-II/VLP formation | |
| 6972 | C/T | — | 5/14 | ||
| 6996 | G/A | — | 5/14 |
(—) Synonymous variations with regard to the prototype reference K02718.1. Del: deletion, Ins: insertion, H: histidine, Y: tyrosine, T: threonine, N: asparagine, D: aspartic acid, A: alanine, S: serine, P: proline, and Q: glutamine.