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. 2015 Feb 22;2015:762506. doi: 10.1155/2015/762506

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Copyright © 2015 Ana Lucía Rodríguez-Perea et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Statins increase the frequency of CD4⁺FOXP3⁺ Treg and mRNA FOXP3. The frequency (a) and absolute number (b) of CD4⁺FOXP3⁺ cells were evaluated by flow cytometry. Methylation percentage in the Treg cell-specific-demethylated-region (TSDR) of FOXP3 gene, in DNA of PBMC from individuals before treatment and 30 days after ongoing treatment, is shown (c). FOXP3 mRNA expression relative to UBC housekeeping gene (d). Median, interquartile range (IQR), and P values are shown in the graph; difference between days was tested by Wilcoxon signed-rank test.