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. 2014 Dec 29;2014:530501. doi: 10.1155/2014/530501

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Copyright © 2014 Guang-ping Ruan et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(a–e) Spleen H&E staining (200x magnification). (a) C57BL/6 mouse normal control group. (b) B6.Fas mouse model group. The arrow indicates megakaryocytes. (c) B6.Fas mouse low-dose group. (d) B6.Fas mouse medium-dose group. (e) B6.Fas mouse high-dose group. The B6.Fas mouse model group displayed visible hemosiderin staining, which improved after treatment. (f–j) Liver H&E staining (200x magnification). (f) C57BL/6 mouse normal control group. (g) B6.Fas mouse model group. The arrow shows necrotic liver cells. (h) B6.Fas mouse low-dose group. (i) B6.Fas mouse medium-dose group. (j) B6.Fas mouse high-dose group. The B6.Fas mouse model group displayed visible spots of necrotic liver cells, which improved after treatment. (k–o) Kidney H&E staining (200x magnification). (k) C57BL/6 mouse normal control group. (l) B6.Fas mouse model group. The arrow shows reduced renal cysts. (m) B6.Fas mouse low-dose group. (n) B6.Fas mouse medium-dose group. (o) B6.Fas mouse high-dose group. The B6.Fas mouse model group displayed slightly proliferative mesangial cells and reduced renal cysts, which improved after treatment. (p–t) Lung H&E staining (200x magnification). (p) C57BL/6 mouse normal control group. (q) B6.Fas mouse model group. The arrow shows inflammatory cell infiltration. B6.Fas mouse low-dose group. (s) B6.Fas mouse medium-dose group. (t) B6.Fas mouse high-dose group. The B6.Fas mouse model group displayed visible alveolar septal infiltration of inflammatory cells, which improved after treatment. (u–y) Renal Masson staining. (u) C57BL/6 mouse normal control group (200x magnification). (v) B6.Fas mouse model group (400x magnification). The arrow shows fibrosis of the tubulointerstitial renal cortex. (w) B6.Fas mouse low-dose group (200x magnification). (x) B6.Fas mouse medium-dose group (400x magnification). (y) B6.Fas mouse high-dose group (200x magnification). The B6.Fas mouse model group displayed slight fibrosis of the tubulointerstitial renal cortex, which improved after treatment. Arrows show the abnormal area.