Table 2. Individual Pharmacokinetic Parameters for Ceftriaxone.
| Volumes of Distribution | Half-life | Clearance | r2 | ||||||
|---|---|---|---|---|---|---|---|---|---|
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| Central | Total | Distribution | Elimination | ||||||
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| Patient | Dose (gm/day) | Baseline Weight (kg) | INFT (hr) | (Liters) | (Liters) | (hr) | (hr) | (mL/min) | |
| 002 | 2 | 98.1 | 0.367 | 7.1 | 13.6 | 0.96 | 9.3 | 17.0 | 1.00 |
| 005 | 2 | 49.8 | 0.417 | 6.2 | 10.7 | 1.46 | 6.5 | 19.0 | 0.99 |
| 007 | 2 | 83.9 | 0.333 | 6.9 | 14.5 | 0.96 | 11.0 | 15.2 | 0.99 |
| 012 | 2 | 117 | 0.417 | 11.7 | 22.5 | 1.75 | 11.2 | 23.1 | 0.99 |
| 015 | 2 | 75.5 | 0.417 | 8.0 | 11.3 | 0.98 | 6.0 | 21.9 | 0.99 |
| 018 | 2 | 74.5 | 0.367 | 6.1 | 10.2 | 1.10 | 6.9 | 17.1 | 0.99 |
| 019 | 2 | 59 | 0.433 | 5.9 | 14.7 | 1.25 | 11.7 | 14.5 | 0.99 |
| 025 | 2 | 78.5 | 0.367 | 0.6 | 9.8 | 0.05 | 7.1 | 15.9 | 1.00 |
| 029 | 2 | 69.5 | 0.533 | 8.0 | 16.1 | 3.05 | 12.2 | 15.3 | 1.00 |
| 032 | 2 | 90.9 | 0.450 | 6.2 | 13.1 | 1.57 | 9.1 | 16.6 | 1.00 |
| 035 | 2 | 80.2 | 0.417 | 6.3 | 11.2 | 1.31 | 8.3 | 15.6 | 1.00 |
| 037 | 2 | 75 | 0.500 | 6.1 | 9.8 | 0.79 | 7.7 | 14.7 | 1.00 |
| 040 | 2 | 97 | 0.500 | 7.4 | 13.3 | 0.71 | 9.6 | 16.0 | 0.99 |
| 045 | 2 | 79.6 | 0.367 | 8.0 | 14.5 | 1.98 | 9.1 | 18.5 | 1.00 |
| 048 | 2 | 81.7 | 0.500 | 7.1 | 15.4 | 1.63 | 13.2 | 13.5 | 0.99 |
| 049 | 2 | 92.6 | 0.350 | 7.1 | 14.9 | 1.22 | 7.5 | 23.0 | 0.99 |
| 052 | 2 | 75.9 | 0.400 | 8.6 | 13.6 | 1.39 | 8.4 | 18.6 | 0.96 |
| 055 | 2 | 83 | 0.417 | 6.6 | 10.6 | 1.38 | 5.7 | 21.5 | 0.98 |
| 060 | 2 | 70.2 | 0.417 | 4.7 | 8.7 | 0.81 | 7.0 | 14.3 | 1.00 |
| 063 | 2 | 118.8 | 0.400 | 6.6 | 14.1 | 0.83 | 9.7 | 16.8 | 0.98 |
| 065 | 2 | 82.4 | 0.417 | 8.0 | 29.1 | 1.55 | 14.6 | 23.0 | 0.91 |
| 069 | 2 | 64.3 | 0.583 | 4.4 | 10.3 | 1.14 | 7.9 | 15.0 | 0.97 |
| Mean | 81.7 | 0.426 | 6.7 | 13.7 | 1.27 | 9.1 | 17.5 | ||
| SD | 16.4 | 0.063 | 2.0 | 4.6 | 0.58 | 2.4 | 3.1 | ||
| SE | 3.5 | 0.013 | 0.4 | 1.0 | 0.12 | 0.5 | 0.7 | ||
| n | 22 | 22 | 22 | 22 | 22 | 22 | 22 | ||
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| 003 | 4 | 85 | 0.417 | 6.3 | 13.8 | 0.34 | 7.4 | 21.7 | 0.99 |
| 004 | 4 | 80.9 | 0.417 | 8.9 | 31.2 | 0.93 | 11.4 | 31.6 | 0.98 |
| 009 | 4 | 84.6 | 0.417 | 5.9 | 11.9 | 0.43 | 7.2 | 19.0 | 0.99 |
| 010 | 4 | 49 | 0.333 | 5.7 | 8.1 | 0.29 | 6.6 | 14.3 | 0.99 |
| 013 | 4 | 88.3 | 0.483 | 14.0 | 4.7 | 34.2 | 0.91 | ||
| 017 | 4 | 105.2 | 0.350 | 7.8 | 13.0 | 0.56 | 6.4 | 23.3 | 1.00 |
| 021 | 4 | 98.6 | 0.450 | 6.9 | 14.9 | 0.99 | 9.9 | 17.4 | 0.99 |
| 024 | 4 | 99.5 | 0.433 | 6.9 | 12.6 | 0.97 | 8.7 | 16.8 | 0.99 |
| 026 | 4 | 142.0 | 0.417 | 15.0 | 7.1 | 24.3 | 0.99 | ||
| 030 | 4 | 72.3 | 0.400 | 6.6 | 14.2 | 0.41 | 8.0 | 20.5 | 1.00 |
| 033 | 4 | 91.6 | 0.433 | 7.7 | 11.6 | 1.05 | 8.2 | 16.5 | 0.99 |
| 034 | 4 | 80.6 | 0.417 | 2.7 | 9.2 | 0.12 | 5.5 | 19.1 | 0.99 |
| 039 | 4 | 67.5 | 0.417 | 6.4 | 12.5 | 1.03 | 8.5 | 17.0 | 0.99 |
| 041 | 4 | 93.3 | 0.417 | 5.9 | 11.9 | 0.73 | 9.5 | 14.5 | 0.98 |
| 043 | 4 | 66.5 | 0.433 | 5.8 | 11.8 | 0.76 | 10.3 | 13.3 | 0.99 |
| 050 | 4 | 100.5 | 0.467 | 6.6 | 11.3 | 0.59 | 6.8 | 19.2 | 0.99 |
| 054 | 4 | 79.1 | 0.417 | 6.7 | 16.0 | 0.24 | 6.5 | 28.5 | 0.97 |
| 057 | 4 | 74 | 0.417 | 7.0 | 15.9 | 1.38 | 9.2 | 20.0 | 0.99 |
| 061 | 4 | 56.4 | 0.417 | 7.4 | 19.9 | 2.01 | 12.4 | 18.6 | 0.99 |
| 064 | 4 | 121.4 | 0.383 | 1.9 | 9.9 | 0.11 | 5.8 | 19.7 | 1.00 |
| Mean | 86.8 | 0.417 | 6.3 | 13.9 | 0.72 | 8.0 | 20.5 | ||
| SD | 21.5 | 0.034 | 1.7 | 4.9 | 0.48 | 2.0 | 5.6 | ||
| SE | 4.8 | 0.008 | 0.4 | 1.1 | 0.11 | 0.4 | 1.2 | ||
| n | 20 | 20 | 18 | 20 | 18 | 20 | 20 | ||