Fig. 6.

Protective effects of retinylamine against light-induced retinal degeneration. Mice treated by oral gavage with different doses of retinylamine were kept in the dark for 24 hours and then bleached with 10,000 lux light for 1 hour. (A) Representative OCT images of mouse retinas 3 days after bleaching. (B) Quantification of ONL thickness by OCT. (C) Recovery of 11-cis-retinal in retinas of mice kept in the dark for 7 days after bleaching. The decreased amounts of 11-cis-retinal in the damaged eyes reflect the loss of photoreceptors. (D) Representative scotopic ERG responses of mice kept in the dark for 7 days after bleaching. ○, 0.1 mg; Δ, 0.2 mg; □, 0.5 mg; ▪, vehicle [dimethylsulfoxide (DMSO)].