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. 2015 Mar;87(3):401–409. doi: 10.1124/mol.114.096693

Fig. 5.

Fig. 5.

RPR-induced enhancement of tail current integral at −120 mV is directly proportional to the number of WT subunits contained within a concatenated hERG1 tetramer. (A) Representative current traces for indicated LAn/WT4-n tetrameric hERG1 channels, recorded before and after treatment of oocyte with 30 µM RPR. Channels were activated with 4-second pulse to +20 mV, and tail currents were elicited at a Vret of −120 mV. (B) Bar graphs showing that the fold increase in ∫Itail induced by indicated concentration of RPR is increased (P < 0.0001, one-way analysis of variance) as a function of the number of WT subunits contained in a concatenated tetramer (n = 4–9). (C) Data for 50 µM RPR replotted and analyzed by linear regression (red line; y = 4.74x − 0.3; R2 = 0.96).