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. 2015 Mar;87(3):401–409. doi: 10.1124/mol.114.096693

Fig. 6.

Fig. 6.

Effect of 50 µM RPR on inactivation of concatenated LAn/WT4-n hERG1 tetramers. (A) Fully activated Itail-Vret relationships in the absence and presence of 50 µM RPR for concatenated LAn/WT4-n hERG1 tetramers (n = 4–6). (B) The voltage dependence of inactivation in the absence and presence of 50 µM RPR for concatenated LAn/WT4-n hERG1 tetramers. Smooth curves represent best fits of data to a Boltzmann function (n = 4–6). Values of V0.5-inact and z for inactivation are presented in Table 2. Diagram shown in each panel indicates positioning of WT and L553A hERG1 subunits in the concatenated tetramer. Control versus 50 µM RPR: †P < 0.0001 (two-way analysis of variance).