TABLE 2.
Summary of effects of RPR on the voltage dependence of recovery from inactivation for WT hERG1 monomers and tetramers containing 0–4 L553A (LA) subunits
| Channel Type | Control |
50 µM RPR |
n | ||
|---|---|---|---|---|---|
| V0.5inact (mV) | z | V0.5inact (mV) | z | ||
| WTmonomer | −50.2 ± 1.4 | 0.91 ± 0.01 | −18.4 ± 2.8 | 1.52 ± 0.08 | 7 |
| WT4 | −51.6 ± 1.6 | 0.92 ± 0.02 | −27.6 ± 0.8 | 1.48 ± 0.05 | 6 |
| LA1/WT3 | −55.9 ± 1.9 | 0.92 ± 0.03 | −36.6 ± 1.0 | 1.27 ± 0.08 | 6 |
| WT3/LA1 | −57.1 ± 1.3 | 0.88 ± 0.01 | −33.6 ± 0.8 | 1.38 ± 0.04 | 5 |
| LA2/WT2 | −56.2 ± 1.3 | 0.93 ± 0.04 | −37.2 ± 1.2 | 1.38 ± 0.04 | 4 |
| LA1/WT1/LA1/WT1 | −53.8 ± 1.8 | 0.84 ± 0.01 | −34.8 ± 0.9 | 1.10 ± 0.03 | 5 |
| LA1/WT1/LA2 | −54.1 ± 3.1 | 0.91 ± 0.03 | −42.3 ± 3.8 | 1.07 ± 0.03 | 5 |
| LA3/WT1 | −46.5 ± 3.6 | 0.87 ± 0.03 | −34.6 ± 1.9 | 1.04 ± 0.04 | 4 |
| LA4 | −45.7 ± 5.7 | 0.93 ± 0.01 | −44.7 ± 5.7 | 1.12 ± 0.05 | 4 |