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Cytotoxicity (IC50) of SKI-178 versus vincristine and colchicine
| AML Cell Line | SKI-178 | Vincristine | Colchicine |
|---|---|---|---|
| nM | |||
| HL-60 | 472 ± 2.95 | 2.3 ± 0.016 | 9.5 ± 0.034 |
| HL-60/VCR | 1057 ± 3.06 | 2280 ± 9.3 | 583 ± 2.6 |
| THP-1 | 686.7 ± 1.98 | NA | NA |
| U-937 | 885.4 ± 1.98 | NA | NA |
NA, not available.
