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Effect of MCD diet–induced NASH on systemic exposures of morphine and M3G. Plasma concentration of morphine (A and C) and M3G (B and D) over 150 minutes (A and B) and 240 minutes (C and D) after intravenous administration of 2.5 mg/kg morphine to control (closed circles) and NASH (open squares) rats. Plasma AUC graphs represent means ± S.D. (n = 4–6 for each group). *P ≤ 0.05; ***P ≤ 0.001 (t test).
