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Biliary excretion of morphine and M3G. Cumulative biliary excretion of morphine (A) and M3G (B) in the bile was measured over 150 minutes after intravenous administration of 2.5 mg/kg morphine to control (closed circles) and NASH (open squares) rats. Bile AUC graphs represent means ± S.D. (n = 5 for each group). **P ≤ 0.01 (t test).
