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. 2015 Mar;352(3):420–428. doi: 10.1124/jpet.114.219303

Fig. 5.

Fig. 5.

Reversal of acute opioid tolerance (A) and dependence (B) by PLGA-curcumin nanoparticles. Groups of eight mice received morphine sulfate (100 mg/kg s.c.) to induce acute opioid tolerance and dependence. PLGA-curcumin nanoparticles (2–20 mg/kg p.o.) or saline was administered 15 minutes before a test dose of morphine (10 mg/kg s.c.) or naloxone (10 mg/kg i.p.). PLGA-curcumin nanoparticles dose-dependently reversed the acute opioid tolerance (A) and opioid dependence (B). Data are expressed as the mean ± S.E.M. *P < 0.05; **P < 0.01; ***P < 0.001 compared with the saline group; ##P < 0.01; ###P < 0.001 compared with the morphine (MS) group.