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Activation of three signaling pathways downstream of the D2R in CHO-D2L cells. (A) Recruitment of β-arrestin to the D2R was measured using the PathHunter assay from DiscoveRx. (B) Activation of Gαi/o by the D2R was measured by assessing inhibition of forskolin-mediated cAMP production. (C) Activation of Gβγ by the D2R was assessed by measuring potentiation of PMA-stimulated cAMP accumulation. Data represent the average and S.E.M. of at least three independent experiments.
