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Bias analyses of β-arrestin recruitment in comparison with Gαi/o activation by the D2R. (A) Equimolar comparison. (B) Equiactive comparison. (C) Transduction coefficient. (D) Sigma comparison. Dopamine was used as the reference compound for all the analyses. For the quantitative analyses positive values indicate bias for β-arrestin; negative values indicate bias for Gαi/o. Data represent the average and S.E.M. of at least three independent experiments. *P < 0.05.
