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. 2015 Mar;352(3):480–493. doi: 10.1124/jpet.114.220293

Fig. 6.

Fig. 6.

Bias analyses using the equiactive comparison and transduction coefficients of ERK phosphorylation in comparison with effectors of the D2R. (A) Equiactive comparison of ERK phosphorylation and Gαi/o activation. (B) Equiactive comparison of ERK phosphorylation and Gβγ activation. (C) Equiactive comparison of ERK phosphorylation and β-arrestin recruitment. (D) Analyses using the transduction coefficients of ERK phosphorylation in comparison with Gαi/o activation. (E) Analyses using the transduction coefficients of ERK phosphorylation in comparison with Gβγ activation. (F) Analyses using the transduction coefficients of ERK phosphorylation in comparison with β-arrestin recruitment. Dopamine was used as the reference compound for all the analyses. Positive values indicate bias for ERK phosphorylation; negative values indicate bias for the immediate D2R effector under analysis. Data represent the average and S.E.M. of at least three independent experiments. *P < 0.05.