Fig. 7.
Bias analyses using the equiactive comparison and transduction coefficients of DMR in comparison with effectors of the D2R. (A) Equiactive comparison of DMR and Gαi/o activation. (B) Equiactive comparison of DMR and Gβγ activation. (C) Equiactive comparison of DMR and β-arrestin recruitment. (D) Analyses using the transduction coefficients of DMR in comparison with Gαi/o activation. (E) Analyses using the transduction coefficients of DMR in comparison with Gβγ activation. (F) Analyses using the transduction coefficients of DMR in comparison with β-arrestin recruitment. Dopamine was used as the reference compound for all the analyses. Positive values indicate bias for DMR; negative values indicate bias for the immediate D2R effector under analysis. Data represent the average and S.E.M. of at least three independent experiments. *P < 0.05.