Fig. 5.

Dexamethasone effects the development of anti-asparaginase IgG antibodies. (A) On day 23 [before pretreatment with intraperitoneal single-dose dexamethasone (Dex), triprolidine, cimetidine, or CV-6209], all sensitized mice had elevated anti-asparaginase IgG levels compared with nonsensitized controls (P < 0.04). Mice that received pretreatment with multiple doses of parenteral dexamethasone (with or without triprolidine) on days 0 and 14 before the day 23 blood collection had similar antibody levels as sensitized, nonpretreated mice (P > 0.05). (B) Mice receiving continuous oral dexamethasone starting 0 or 7 days before the asparaginase sensitization had lower measured anti-asparaginase IgG levels compared with sensitized, nonpretreated mice (P = 1.0 × 10⁻³ and 4.1 × 10⁻⁴, respectively) in samples available on day 17 of treatment (before the asparaginase challenge).