Fig. 7.
Asparaginase dose adjustments restored activity levels in sensitized mice. Sensitized mice were challenged with 2-, 5-, or 10-fold higher asparaginase doses. (A) The severity of the reaction (drop in rectal temperature) showed a dose-dependent relationship (P < 1.0 × 10−3 compared with 1×, sensitized), and mice pretreated with triprolidine and CV-6209 receiving a 5-fold higher dose were able to mitigate the reaction relative to nonpretreated mice (P = 9.8 × 10−4). (B) Furthermore, dose adjustments ≥5-fold were able to restore asparaginase activity in samples collected 2 hours after the challenge compared with nonsensitized mice (P > 0.05).