Fig. 1. Changes in G protein-coupled receptor (GPCR) expression in stem cell maintenance and/or during somatic reprogramming to iPSCs or CSCs. The transcriptional profile of the selected GPCR family was analyzed using high-throughput RNA sequencing. (A) GPCRs showing up- or down-regulated expression during stem cell maintenance. (B) GPCRs showing up- or down-regulated expression during somatic reprogramming to iPSCs. (C) GPCRs showing up- or down-regulated expression during CSC sphere formation. (D) GPCRs showing up- or down-regulated expression during malignant transformation (somatic reprogramming) to CSCs.
