| Condition |
Classification |
Family |
Subfamily (Gene) |
|
| Stem cell maintenance |
CLASS A |
Rhodopsin-like
receptors |
A1 (GPR137b, CCR4), A2 (CXCR7, GPR182), A4 (GPR1, GPR22), A5 (GPR100,
GPR106, GPR142, CYSLTR2, GALR3), A6 (GPR103), A7 (GPR39), A8 (GPR44, GPR77,
CMKLR1), A9 (GPR19,GPR50, GPR73, GPR75, GPR83), A10 (GPR48, GPR49, LGR4),
A11 (GPR40, GPR43, GPR81, GPR82, GPR109b), A12 (GPR34, GPR87, GPR171), A13
(GPR3, GPR6, GPR12, MC5R, S1PR2, LPAR1, LPAR2), A14 (PTGER1), A15 (LPAR4,
F2RL1, LPAR5, F2R, GPR4, LPAR6, GPR18, GPR20, GPR35, GPR65, GPR68, GPR119,
GPR132), A17 (ADRB1, ADRB2, ADRB3), A18 (GPR21, GPR27, GPR45, GPR61,
GPR63, GPR84, GPR85, GPR88, GPR173, ADORA2b), Orphan (GPR23, GPR26,
GPR33, GPR35, GPR37, GPR54, GPR83, GPR135, GPR146, GPR149, GPR150,
GPR151, GPR152, GPR153, GPR160) |
|
CLASS B |
Secretin receptor family |
B1 (GLP1R), B2 (GPR56, GPR64, GPR97, GPR110, GPR115, GPR126, GPR125,
GPR128, GPR133, CD97, BAI2, CSLSR1, LPHN2, LPHN1, CELSR3, CELSR2, BAI1),
GPR116 |
|
CLASS C |
Metabotropic
glutamate receptor |
Group II (GRM2), Group VI (GPRC6a), Orphan (GPRC5b, GPRC5c, GPRC5d, GPR156,
GPR158) |
|
Adhesion |
- |
GPR124, GPR126 |
|
CLASS F |
Frizzled |
FZD3, FZD4, FZD5, FZD6, FZD7, FZD9 |
|
|
Smoothened |
SMO |
| Somatic reprogramming
to iPSCs |
CLASS A |
Rhodopsin-like
receptors |
A4 (GPR22, GPR1), A5 (GPR100, GPR106, GPR142), A6 (GPR103), A7 (GPR39), A8
(GPR44, GPR77), A9 (GPR50, GPR73, GPR75, GPR19), A10 (GPR49, GPR48), A11
(GPR82, GPR40, GPR43, GRP109b, GPR81), A12 (GPR87, GPR34, GPR171), A13
(GPR3, GPR12, GPR6), A15 (GPR4, GPR68, GPR119, GPR35, GPR132, GPR18,
GPR65, GPR20), A18 (GPR61, GPR84, GPR85, GPR45, GPR63, GPR88, GPR173,
GPR27, GPR21), Orphan (GPR141, GPR23, GPR26, GPR33, GPR35, GPR37, GPR54,
GPR135, GPR149, GPR150, GPR151, GPR152, GPR153, GPR160) |
|
CLASS B |
Secretin receptor family |
B2 (GPR56, GPR64, GPR97, GPR110, GPR115, GPR126, GPR128, GPR133), GPR116 |
|
CLASS C |
Metabotropic glutamate receptor |
Group VI (GPRC6a), Orphan (GPRC5b, GPRC5c, GPR156, GPRC5d, GPR158) |
| Sphere formation
of CSCs |
CLASS A |
Rhodopsin-like
receptors |
A1 (CCRL2, GPR137b), A2 (CCR10, CXCR4), A4 (OPRL1, SSR1, SSR2, SSR3, SSR4), A5
(GALT, LTB4R), A6 (GPR176), A7 (EDNRA, EDNRB, GPR37, GPR39), A10 (LGR4),
A11 (P2RY2), A13 (LPAR1, LPAR2, S1PR1, S1PR2, MC1R, GPR3), A14 (PTGER4), A15
(LPAR5, F2RL1, F2RL2, F2RL3, GPR68, GPR35, F2R), A16 (OPN3), A17 (ADRB2), A18
(HRH1, ADORA1, ADORA2B, GPR64, GPR161, GPR173), A19 (HTR7) |
|
CLASS B |
Secretin receptor
family |
B1 (CRHR1, GIPR, VIPR1) |
|
CLASS F |
Frizzled |
FZD1, FZD2, FZD4, FZD5, FZD6, FZD7, FZD8 |
| Somatic
reprogramming
to CSCs |
CLASS A |
Rhodopsin-like
receptors |
A1 (CCR2, CCR3, CCR4, CR8, CCRL2, CX3CR1, GPR137b), A2 (CCR6, CCR7, CCR9,
CCRL1, CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, CXCR6, CXCR7, PER, GPR182), A3
(GPR15, GPR25), A4 (GPR1, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5), A5 (CYSLTR1,
CYSLTR2, GALR1 GALR2, GALR3, RXFP1, RXFP2, RXFP4), A6 (AVPR1b, CCKAR,
CCKBR, GNRHR, GPR176, GPR22, HCRTR2, QRFPR), A7 (BRS3, EDNRB, GHSR,
GPR37, GPR39, GPRP, TRHR), A8 (C3AR1, CMKLR1, FPR1, GPR1, GPR32, GPR77),
A9 (GPR19, GPR50, PPYR1, PRLHR, PROKR1, PROKR2, TACR1, TACR2, TACR3), A10
(TSHR), A11 (FFAR1, FFAR2, FFAR3, GPR31, GPR82, HCAR1, HCAR2, HCAR3,
OXGR1, P2RY1, P2RY11, P2RY2, P2RY4, P2RY6, PWRY8), A12 (GPR171, GPR87,
P2RY13, P2RY14, PTAFR), A13 (CNR1, CNR2, GPR12, GPR3, GPR6, S1PR1, S1PR2,
S1PR4, S1PR5), A14 (PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGER, PTGIR,
TBXA2R), A15 (F2R, F2RL1, F2RL2, F2RL3, GPR132, GPR17, GPR183, GPR35, GPR65,
P2RY10), A16 (RGR, RHO, RRH), A17 (DRD1, DRD2, DRD4, HRH2, HTR2A, HTR2B,
HTR2C, HTR6, TAAR1, TAAR2, TAAR3, TAAR5, TAAR6), A18 (CHRM1, CHRM2,
CHRM4, GPR161, GPR173, GPR21, GPR27, GPR45, GPR52, GPR61, GPR63, GPR78,
GPR85, GPR88, HRH1, HRH3, HRH4), A19 (HTR1D, HTR1F, HTR4, HTR7) |
|
CLASS B |
Secretin receptor
family |
B1 (CRHR1, CRHR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, SCTR), B2 (BAI2, BAI3,
CD97, CELSR1, ELTD1, EMR1, EMR2, EMR3, GPR110, GPR111, GPR113, GPR114,
GPR115, GPR123, GPR125, GPR126, GPR128, GPR144, GPR56, GPR64) |
|
CLASS C |
Metabotropic glutamate receptor |
Group I (GRM1, GRM5), Group II (GRM4, GRM7, GRM8), Group III (GRM2, GRM3) |
|
CLASS F |
Frizzled |
FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10 |
